The Iowa State University Cryo-EM Facility is an Office of Biotechnology core in the Molecular Biology Building supporting single particle cryo-EM of viruses, macromolecular complexes, and nanoparticles. It operates a 200 kV Glacios with X-FEG, cryo-autoloader, and Gatan K3 detector using EPU and SerialEM, with a Vitrobot Mark IV for vitrification and a Refeyn TwoMP mass photometer. Data processing uses a 250 TB local store and the Pronto GPU cluster, and services are open to ISU, other academic, and industry users.
Open to ISU, other academic institutions, and private companies; new users contact the facility manager and submit a project proposal form, with separate internal and external rates.
TEM
Glacios
Thermo Fisher Scientific
Sample Prep
Refeyn 2MP Mass Photometer
Refeyn
Sample Prep
Vitrobot Mark IV
Thermo Fisher Scientific
Other Iowa facilities that take external users
- Protein Structure, Analysis, & Design (PSAD) Core
University of Iowa · Iowa City, IA
External users
Private providers that run samples
Companies that run cryo-EM as a paid service: you ship a sample, they prepare grids and collect data, and several also process it.
- Creative Biostructure ↗
Shirley, NY
Private providerDirectory page - FairJourney Biologics ↗
San Diego, CA
Private providerDirectory page - Helix Biostructures ↗
Indianapolis, IN
Private providerDirectory page - NanoImaging Services ↗
San Diego, CA
Private providerDirectory page - NovAliX ↗
Strasbourg, France
Private providerDirectory page - Proteros Biostructures ↗
Martinsried, Germany
Private providerDirectory page - Selvita (Cryo-EM Services) ↗
Cambridge, MA
Private providerDirectory page - Thermo Fisher Cryo-EM Drug Discovery Center ↗
South San Francisco, CA
Private providerDirectory page
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