Cryo-EM✓ External Access

Proteros Cryo-EM Services (Cryo-EM Center of Excellence)

Proteros Biostructures

📍 Martinsried, Germany · Website ↗

Proteros Biostructures GmbH is a drug discovery CRO headquartered at Bunsenstrasse 7a, 82152 Martinsried (Planegg, near Munich), Germany, with a North American office at One Broadway, Cambridge, MA. Its cryo-EM Center of Excellence, launched in September 2020 in collaboration with Thermo Fisher Scientific, operates an in-house Glacios cryo-TEM with a Falcon 4 direct electron detector alongside a Vitrobot Mark IV and Tecnai Spirit and Philips CM100 microscopes for negative staining. The service is offered in three modules (protein sciences, EM feasibility analysis, structure determination) with 12 h Glacios datasets and 24-72 h datasets on the Glacios or on a Titan Krios accessed externally.

Equipment Inventory(4 instruments)

Roster verified against the facility's own published instrument list, September 2026.

Vitrobot Mark IV

Thermo Fisher Scientific · Vitrification

Sample Prep
Configuration: Plunge freezer for cryo-grid preparation

Glacios

Thermo Fisher Scientific · Single Particle / Screening

TEM
Voltage: 200 kV
Configuration: 200 kV in-house cryo-TEM with Falcon 4 direct electron detector; installed 2020 at Martinsried headquarters as a Thermo Fisher Center of Excellence; used for 12 h screening datasets and 24-72 h data collection

Tecnai T12

Thermo Fisher Scientific

TEM
Configuration: Room-temperature TEM used for negative-stain EM feasibility screening; page wording is 'microscopes access', ownership not stated explicitly

Philips CM100

Philips · Screening / Negative Stain

TEM
Configuration: Room-temperature TEM used for negative-stain EM feasibility screening; page wording is 'microscopes access', ownership not stated explicitly