Guides & Resources
Expert guides on cryo-EM and mass spectrometry core facilities — pricing, equipment comparisons, access policies, and best practices.
Cryo-EM Sample Preparation: Best Practices
From protein purification to grid vitrification. Vitrobot vs. Chameleon, grid types, ice thickness optimization, and troubleshooting common problems.
Cryo-EM Pricing Guide 2026
How much does cryo-EM cost? Comprehensive breakdown of cryo-EM pricing and hourly rates at academic core facilities and private CROs across the United States.
Titan Krios vs. Glacios: Which Do You Need?
Head-to-head comparison of the two most popular cryo-EM microscopes for structural biology.
How to Access Cryo-EM as an External User
Step-by-step guide for researchers at institutions without cryo-EM capabilities.
Mass Spectrometry Core Facility Guide
How to choose the right mass spectrometry facility for your proteomics, metabolomics, or structural biology project.
Mass Spectrometry Proteomics: A Complete Guide
Comprehensive introduction to mass spectrometry-based proteomics — instruments, workflows, data analysis, and how to find the right core facility for your project.
How Does Cryo-EM Work? A Beginner's Guide
Plain-language explanation of cryo-electron microscopy — how samples are frozen, imaged, and reconstructed into 3D molecular structures.
Cryo-EM vs. X-Ray Crystallography: How to Choose
A practical comparison of the two major structural biology techniques — when to use cryo-EM, when to use crystallography, and when to combine both.
Negative Stain Electron Microscopy: When and How to Use It
Practical guide to negative stain EM — sample preparation, imaging, and when to use it before committing to cryo-EM.
Single Particle Cryo-EM: Methods, Applications & Best Practices
Deep dive into single particle analysis — from sample optimization through data collection to 3D reconstruction and model building.
Cryo-EM Jobs & Careers: Your Complete Guide
Everything you need to know about careers in cryo-electron microscopy — job types, required skills, salary ranges, and where to find openings.