Guides & Resources
Expert guides on cryo-EM and mass spectrometry core facilities: pricing, equipment comparisons, access policies, and best practices.
Cryo-EM Cost 2026: Titan Krios Price per Hour, Day and Project
Titan Krios time costs $30–124/hr for internal academic users, $47–183/hr for external academics and $125–381/hr for industry, from 14 facilities' published rate sheets. Plus what a Krios costs to buy and what data processing adds.
Cryo-EM Sample Preparation: Best Practices
From protein purification to grid vitrification. Vitrobot vs. Chameleon, grid types, ice thickness optimization, and troubleshooting common problems.
AI Training Work for Scientists: The Honest Guide
AI labs pay PhD experts $30–100+/hr to create and grade training data. What the work is, what it pays, how variable it really is, and where to sign up.
Expert Network Calls for Scientists: How GLG Works
Consultants and investors pay scientists by the hour to explain their field on a phone call. How GLG membership works, what you can charge, what the calls are like, and the compliance rules.
Titan Krios vs. Glacios: Which Do You Need?
Head-to-head comparison of the two most popular cryo-EM microscopes for structural biology.
How to Access Cryo-EM as an External User
Step-by-step guide for researchers at institutions without cryo-EM capabilities.
Mass Spectrometry Core Facility Guide
How to choose the right mass spectrometry facility for your proteomics, metabolomics, or structural biology project.
Mass Spectrometry Proteomics: A Complete Guide
Comprehensive introduction to mass spectrometry-based proteomics: instruments, workflows, data analysis, and how to find the right core facility for your project.
How Does Cryo-EM Work? A Beginner's Guide
Plain-language explanation of cryo-electron microscopy: how samples are frozen, imaged, and reconstructed into 3D molecular structures.
Cryo-EM vs. X-Ray Crystallography: How to Choose
A practical comparison of the two major structural biology techniques: when to use cryo-EM, when to use crystallography, and when to combine both.
AlphaFold vs. Cryo-EM: When You Still Need the Microscope
Structure prediction answers the first question about a new protein but not the ones that follow. Where prediction stops, where cryo-EM starts, and how to use them together, with a worked example from a published structure.
Negative Stain Electron Microscopy: When and How to Use It
Practical guide to negative stain EM: sample preparation, imaging, and when to use it before committing to cryo-EM.
Single Particle Cryo-EM: Methods, Applications & Best Practices
Deep dive into single particle analysis: from sample optimization through data collection to 3D reconstruction and model building.
Cryo-EM Jobs & Careers: Your Complete Guide
Everything you need to know about careers in cryo-electron microscopy: job types, required skills, salary ranges, and where to find openings.
Cryo-EM Troubleshooting: Is the Sample or the Processing Your Bottleneck?
Weeks get lost reprocessing data that no algorithm can rescue, and samples get remade when one classification job would have solved it. The diagnostics that tell you which side of the microscope your problem lives on.