Cryo-EM✗ Internal Only

Center for Structural Biology Cryo-EM Facility (CCR)

National Cancer Institute

📍 Bethesda, MD · Website ↗

The CSB Cryo-EM Facility is the NCI Center for Cancer Research intramural cryo-EM core on the Bethesda campus, distinct from the National Cryo-EM Facility (NCEF) at the Frederick National Laboratory, and it primarily serves CSB and CCR investigators with time also available to other NCI and NIH intramural groups after committee review. It operates a 300 kV Titan Krios G4 with cold FEG, Selectris X filter and Falcon 4i, a 200 kV Talos Arctica G2 with BioQuantum K3, a Talos L120C and an Aquilos 2 cryo-FIB-SEM.

Center for Structural Biology Cryo-EM Facility (CCR) serves its own institution only. These can take outside samples:

Maryland facilities that take external users

Private providers that run samples

Contact providers directly. We don't broker quotes or pass on your details.

Equipment Inventory(7 instruments)

Roster verified against the facility's own published instrument list, September 2026.

Aquilos 2

Thermo Fisher Scientific · Cryo-FIB Milling

FIB-SEM
Configuration: cryo-FIB-SEM with integrated fluorescence light microscope (iFLM)

chameleon

SPT Labtech

Sample Prep
Configuration: blot-free vitrification

Vitrobot Mark IV

Thermo Fisher Scientific · Vitrification

Sample Prep

Leica EM GP2

Leica Microsystems · Vitrification

Sample Prep
Configuration: automatic plunge freezer

Talos Arctica

Thermo Fisher Scientific · Single Particle / Screening

TEM
Voltage: 200 kV
Configuration: 200 kV, X-FEG, Gatan BioQuantum energy filter, K3 direct electron detector

Talos L120C

Thermo Fisher Scientific · Screening / Negative Stain

TEM
Voltage: 120 kV
Configuration: 120 kV, ambient and cryogenic imaging

Titan Krios G4

Thermo Fisher Scientific · Single Particle / Tomography

TEM
Voltage: 300 kV
Configuration: 300 kV, E-CFEG cold field emission gun, Selectris X energy filter, Falcon 4i direct electron detector