Postdoctoral Research Assistant in Structural Biology

Postdoctoral Research Assistant in Structural Biology University of Oxford, United Kingdom Application deadline: 31 Jul 2026 We are seeking an ambitious Postdoctoral Research Assistant to join the laboratory of Dr Georgia Isom at the Sir William Dunn School of Pathology, University of Oxford, to uncover the molecular machinery that transports sphingolipids to the surface of Gram-negative bacteria. This exciting project combines cryo-electron microscopy, native mass spectrometry, proteomics, and bacterial cell biology to answer a fundamental question in bacterial membrane biology. For decades, sphingolipids were thought to be almost exclusively eukaryotic membrane components, with only a handful of unusual bacteria capable of producing them. Our recent discoveries have overturned this view, revealing that sphingolipid biosynthesis is widespread across diverse bacteria. Emerging evidence suggests sphingolipids are key determinants of membrane homeostasis, environmental adaptation, antimicrobial resistance and host-pathogen interactions. Yet one of the biggest questions in the field remains unanswered: how are sphingolipids transported across the bacterial cell envelope to reach the cell surface? The post-holder should hold, or be close to completion of, a PhD in structural biology and have experience of solving high resolution structures using single particle cryo-EM. You should be highly motivated, organised and able to work independently as well as part of a team. This is a fixed-term appointment available for 2 years in the first instance (with funds to extend) with the position available from autumn/winter 2026. If you are interested in this role, and have the skills and experience we are looking for, please apply online. You will be required to upload a CV and supporting statement as part of your online application. Informal enquiries could be sent to Dr Georgia Isom via email: [georgia.isom@path.ox.ac.uk](mail to:georgia.isom@path.ox.ac.uk). Only applications submitted online and received before noon Friday 31st July 2026 will be considered. Interviews will be held soon thereafter. For more information and to apply, visit our website.