Cryo-EM✓ External Access

Multiscale Microscopy Core (MMC)

Oregon Health & Science University

📍 Portland, OR · Website ↗

The Multiscale Microscopy Core is OHSU's institutional electron microscopy core, located in the Robertson Life Sciences Building on the South Waterfront campus. It operates a Glacios cryo-TEM, a Tecnai T12 with iCorr, two Helios DualBeam FIB-SEMs (one with cryo stage), a VolumeScope II serial block-face SEM, a CorrSight CLEM system and a Vitrobot, and a Talos L120C was funded for installation in winter 2024. The NIH-funded Pacific Northwest Center for Cryo-EM (PNCC), which houses four Titan Krios, one Talos Arctica and a Glacios 2, is a separate national user facility in the same building operated by OHSU and PNNL and is accessed through peer-reviewed proposals, not through the MMC.

Equipment Inventory(13 instruments)

Roster verified against the facility's own published instrument list, September 2026.

Helios 5 UC DualBeam

Thermo Fisher Scientific

FIB-SEM
Configuration: Ultim Extreme Oxford EDS detector; Leica cryostage for cryo-FIB

Helios NanoLab G3 DualBeam

FEI / Thermo Fisher Scientific

FIB-SEM
Configuration: Room-temperature DualBeam FIB-SEM

CorrSight

FEI / Thermo Fisher Scientific

Other
Configuration: Correlative light and electron microscopy (CLEM) light microscope

Vitrobot Mark IV

Thermo Fisher Scientific · Vitrification

Sample Prep
Configuration: Plunge freezer for grid vitrification.

Leica EM FC7

Leica Microsystems · Cryo-Ultramicrotome

Sample Prep
Configuration: Cryo-ultramicrotome

Wohlwend HPF

Wohlwend

Sample Prep
Configuration: High-pressure freezer

Leica EM AFS2

Leica Microsystems · Freeze Substitution

Sample Prep
Configuration: Freeze substitution and low temperature embedding

Pelco easiGlow

Ted Pella · Glow Discharge

Sample Prep
Configuration: Glow discharge cleaning system

Leica EM ACE600

Leica Microsystems · Coater

Sample Prep
Configuration: High-vacuum coater

Leica EM UC7

Leica Microsystems · Ultramicrotome

Sample Prep
Configuration: Ultramicrotome

VolumeScope 2

Thermo Fisher Scientific · Serial Block-Face

SEM
Configuration: Serial block-face SEM (Apreo-based)

Tecnai T12

Thermo Fisher Scientific

TEM
Configuration: Tecnai 12 with iCorr integrated light microscope; Eagle 2K CCD and MegaView G2 side-mount CCD; cryo shields; listed as T12 Spirit on services form

Glacios

Thermo Fisher Scientific · Single Particle / Screening

TEM
Voltage: 200 kV
Configuration: 200 kV cryo-TEM for frozen hydrated samples; detector not stated

Published Rates

As published by the facility, retrieved Aug 10, 2026 · source. Rates change; confirm with the facility before budgeting.

ServiceRateApplies toNotes
Glacios (with technician, hourly)$176/hourexternalacademic
Glacios (with technician, hourly)$402/hourindustrynon-academic
Glacios (independent, hourly)$77/hourinternalFY24
Glacios (with technician, hourly)$153/hourinternalFY24; internal academic
Tecnai T12 (independent, hourly)$66/hourinternalFY24
Tecnai T12 (with technician, hourly)$142/hourinternalFY24