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Stanford-SLAC CryoEM Center (S2C2)

Stanford University / SLAC National Accelerator Laboratory

📍 Menlo Park, CA · Website ↗

One of three NIH Common Fund Transformative High-Resolution Cryo-EM national service centers, located at SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, CA. Provides high-resolution single-particle and tomography data collection on four Titan Krios microscopes plus a Glacios 2 and a Tundra, along with specimen preparation devices, remote operation, and training residencies. Closely affiliated with the separately funded Stanford-SLAC CryoET Specimen Preparation Center (SCSC) in the same building.

Equipment Inventory(11 instruments)

Roster verified against the facility's own published instrument list, September 2026.

Vitrobot

Thermo Fisher Scientific

Sample Prep
Configuration: Plunge freezer for grid vitrification.

VitroJet

CryoSol-World · Vitrification

Sample Prep
Configuration: Quantity not stated.

Gatan CP3

Gatan · Vitrification

Sample Prep
Configuration: Cryoplunge 3; quantity not stated.

Leica EM ACE600

Leica Microsystems · Coater

Sample Prep
Configuration: Sputter coater.

Refeyn 2MP Mass Photometer

Refeyn

Sample Prep
Configuration: Sample QC; model not stated.

Leica EM GP2

Leica Microsystems · Vitrification

Sample Prep
Configuration: Quantity not stated.

chameleon

SPT Labtech

Sample Prep
Configuration: Blot-free plunger; quantity not stated.

Titan Krios G4

Thermo Fisher Scientific · Single Particle / Tomography

TEM
Voltage: 300 kV
Configuration: Delta: 300 keV CFEG, Falcon 4i, Ceta 2, Selectris X.

Glacios 2

Thermo Fisher Scientific · Single Particle / Screening

TEM
Voltage: 200 kV
Configuration: 200 keV XFEG, Falcon 4i, Ceta-D, Selectris filter; EPU Multigrid, Tomo 5, SerialEM 4, EPU-D.

Tundra

Thermo Fisher Scientific · Screening

TEM
Voltage: 100 kV
Configuration: 100 keV XFEG, Falcon C, Ceta F, DE Centurion; Smart-EPU.

Titan Krios G3i

×3

Thermo Fisher Scientific · Single Particle / Tomography

TEM
Voltage: 300 kV
Configuration: Alpha: 300 keV CFEG, Falcon 4i, Ceta 16M, Ceta 2, Selectris X. Beta: 300 keV XFEG, Gatan K3, Ceta 16M, BioQuantum. Gamma: 300 keV CFEG, Falcon 4i, Ceta-D, Selectris X. Software EPU Multigrid, TFS Tomo 5, SerialEM 4.