How this application is scored, and how to structure it
Shared Instrumentation Grant (SIG) Program (S10 Clinical Trial Not Allowed)
National Institutes of Health
Deadline: July 1, 2028(659 days)
Shared instrumentation (NIH S10 / NSF MRI style)
Instrumentation awards are judged on justified NEED and shared USE, not on a single research project. NIH S10 requires multiple Major Users, each typically a PD/PI on a distinct active research award — verify the current requirement in the announcement.
Set by the funder — check the announcement.
What reviewers score
Need & Justification
see announcement- Reviewers are asked
- Is the instrument genuinely needed, and is the specific model justified over cheaper alternatives?
- So write
- Document current bottlenecks with real numbers: wait times, samples shipped elsewhere, experiments not attempted. Justify the exact configuration.
- Commonly loses points for
- Wish-list request with no demonstrated bottleneck
- No comparison to alternative instruments
Major Users & Shared Use
see announcement- Reviewers are asked
- Is there a strong, funded user base, and will access be equitable?
- So write
- Per Major User: their funded project, the specific experiments needing this instrument, and estimated hours. Include a governance and scheduling plan.
- Commonly loses points for
- Users without active funding
- One dominant user — reads as a single-lab instrument
Institutional Commitment & Management
see announcement- Reviewers are asked
- Will the institution house, staff, and maintain it?
- So write
- Named space, committed technical staff, service-contract funding after year one, and an oversight committee.
- Commonly loses points for
- No committed operator
- Silence on maintenance costs beyond the award
Section-by-section outline
1.Instrument Justification
Per announcementProve need and configuration choice.
Must include
- Quantified current bottleneck
- Configuration rationale
- Alternatives considered
Avoid
- Qualitative need only
2.Major User Projects
Per announcementProve a funded, shared user base.
Must include
- Each user's funded award
- Experiments requiring the instrument
- Requested hours
Avoid
- Unfunded or speculative users
3.Management & Institutional Commitment
Per announcementProve sustainability.
Must include
- Space, staffing, service contract
- Access policy and governance
- Fee structure
Avoid
- No plan for ongoing costs
Strategy notes for this mechanism
- S10-style awards are won on the strength of the user base, not the elegance of one project.
- Confirm the current Major User requirement in the announcement before assembling the team.
Eligibility for this opportunity: Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/Foreign Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Structure and review criteria are compiled from published funder guidance and were verified in July 2026. NIH revises these, so confirm against the current announcement before you submit. This is drafting scaffolding, not a substitute for your programme officer or research development office.