S10 HEI

NIH S10 High-End Instrumentation Grant (HEI)

NIH ORIP

Award amount
$750,001 – $2,000,000 (1 year, no indirect costs)
Deadline
Annual — applications due ~June 1
Who can apply
Early-career / assistant professor · Faculty / independent investigators
Region
US

About this grant

Buy high-end instruments such as Krios-class microscopes. The highest-value mechanism for a core facility upgrading capability.

Eligibility details

Requires at least 3 Major Users, each a PD/PI on a distinct active NIH research award (training/fellowship T and F grants do not count).

Research areas

instrumentationcryo-EM
View on NIH ORIP →Get matched to what you're eligible for

Related funding

NCCAT — Free Krios access & training
NIGMS / New York Structural Biology Center
Free
PNCC — Free cryo-EM data collection & compute
NIGMS / OHSU + PNNL
Free
S²C² — Stanford-SLAC Cryo-EM Center (free access)
NIGMS / SLAC National Accelerator Laboratory
Free
NIH S10 Shared Instrumentation Grant (SIG)
NIH ORIP
$50,000 – $750,000 (1 year, no indirect costs)
NSF Major Research Instrumentation (MRI)
National Science Foundation
Track 1: $100k–$1.4M · Track 2: $1.4M–$4M
W. M. Keck Foundation — Research Program
W. M. Keck Foundation
Typically $1M+

Verified best-effort. Amounts, deadlines, and eligibility change — always confirm on the funder's own page before applying.