Engineering of Biomedical Systems

About this grant

TheEngineering of Biomedical Systemsprogram is part of the Engineering Biology and Health cluster, which also includes: 1) theBiophotonicsprogram; 2) theBiosensingprogram; 3) theCellular and Biochemical Engineeringprogram; and 4) theDisability and Rehabilitation Engineeringprogram. The goal of theEngineering of Biomedical Systems(EBMS) program is to provide opportunities for fundamental and transformative research projects that integrate engineering and life sciences to solve biomedical problems and serve humanity in the long term. Projects are expected to use an engineering framework (for example, design or modeling) that supports increased understanding of physiological or pathophysiological processes. Projects must include objectives that advance both engineering and biomedical sciences. Projects may include: methods, models, and enabling tools applied to understand or control living systems; fundamental improvements in deriving information from cells, tissues, organs, and organ systems; or new approaches to the design of systems that include both living and non-living components for eventual medical use in the long term. TheEBMS programsupports fundamental and transformative research in the following areas of biomedical engineering: Developmentof validated models (living or computational) of healthy and pathological tissues and organ systems that can support improved fundamental understanding of these systems or that could be applied in the future for development and testing of medical interventions; Designand validation of systems that integrate living and non-living componentsfor improved understanding of physiology that could be applied in the future for diagnosis, monitoring, and treatment ofdisease or injury; Design and subsequent application of technologies andtools toinvestigate fundamental physiological and pathophysiological processes; Advancedbiomanufacturing of three-dimensional tissues and organs; and Application of engineering tools and principles, including mathematical modeling, to quantitatively study the immune system in health and disease and to develop techniques for controlling and modulating a host’s immune response to challenges such as infectious diseases, cancer, implants, autoimmune disorders, wounds, etc. The long-term impact of the projects can be related to effective disease diagnosis and/or treatment, or improved health care delivery. However, immediate goals should focus on improved fundamental understanding of cell and tissue function in normal or pathological conditions and advancing biomedical engineering. Innovative proposals outside of these specific areas of biomedical engineering may be considered.However, prior to submission, it is strongly recommended that the PIs contact the program director to avoid the possibility of the proposal being returned without review. Related programs also fund biomedical engineering research, and PIs are encouraged to examine these to find the appropriate program for submission. The EBMS program does not support proposals having as their central theme drug design and delivery, the development of biomedical devices that do not include a living biological component, or thedevelopment of animal models of disease.For consideration by the EBMS program, proposals that advance the design of tools or technologies should also apply those technologies to advance knowledge in biomedical science. NSF does not support clinical trials; however, feasibility studies involving human volunteers may be supported if appropriate to the project objectives. Projects with a central focus on design or optimization of a device, material, algorithm, or process alone without exploring new fundamental biomedical science are not appropriate for the EBMS program. Furthermore, although research on biomaterials, cellular biomechanics, manufacturing systems, or algorithm/device design may constitute a part of the proposed studies, such research can be more appropriately targeted to other

Research areas