Cryo-EM✗ Internal Only

Penn State College of Medicine Cryo-EM Core

Penn State College of Medicine

📍 HERSHEY, PA · Website ↗

The Cryo-Electron Microscopy Core at Penn State College of Medicine in Hershey was established in 2020 and is separate from the Huck Institutes facility at University Park. It operates a 300 kV Titan Krios G3i with a Gatan K3 and BioQuantum energy filter, a 200 kV JEOL JEM-2100 with cryo holder, a Hydra plasma cryo-FIB-SEM, a Zeiss LSM 980 cryo-confocal and a Vitrobot Mark IV.

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Equipment Inventory(5 instruments)

Roster verified against the facility's own published instrument list, September 2026.

Hydra Bio

Thermo Fisher Scientific

FIB-SEM

Configuration: listed as Hydra cryo-FIB-SEM with high pressure freezing support; exact variant not stated

Zeiss LSM 980

Zeiss

Other

Configuration: cryo-confocal with Linkam cryostage, Airyscan 2, 7-laser system

Vitrobot Mark IV

Thermo Fisher Scientific · Vitrification

Sample Prep

JEOL JEM-2100

JEOL

TEM

Configuration: 200 kV, cryo box, Gatan side-entry cryo holder, Gatan Ultrascan 4k x 4k CCD

Titan Krios G3i

Thermo Fisher Scientific · Single Particle / Tomography

TEM

Voltage: 300 kV

Configuration: 300 kV with Volta phase plate, Gatan K3 and BioQuantum energy filter. Hershey campus core, established 2020.