Cryo-EM✓ External Access

Harvard Cryo-Electron Microscopy Center for Structural Biology (HC2EM)

Harvard University

📍 Boston, MA · Website ↗

Joint HMS, Dana-Farber, Boston Children's Hospital and MGH center that opened to users in February 2019 in Room B04 of the Seeley G. Mudd building, 250 Longwood Avenue, Boston (Longwood campus, not Cambridge). It operates Titan Krios 300 kV microscopes (Krios2 with Falcon 4i and Selectris energy filter), a Talos Arctica 200 kV with Gatan K3, and Vitrobot Mark IV plungers, with staff consultation and training available to users outside HMS. It is distinct from the Cambridge-campus Glacios 2 facility run by the Harvard Center for Biological Imaging (HCBI) in the LISE building.

Equipment Inventory(3 instruments)

Roster verified against the facility's own published instrument list, September 2026.

Vitrobot Mark IV

Thermo Fisher Scientific · Vitrification

Sample Prep
Configuration: Plunge freezer for grid vitrification.

Talos Arctica

Thermo Fisher Scientific · Single Particle / Screening

TEM
Voltage: 200 kV
Configuration: 200 kV with a Gatan K3, used for screening and data collection with SerialEM.
Internal: $49/hrExternal: $80/hr

Titan Krios G3i

×2

Thermo Fisher Scientific · Single Particle / Tomography

TEM
Voltage: 300 kV
Configuration: 300 kV, two instruments named Krios1 and Krios2. Krios2 carries a Falcon 4i with a Selectris energy filter.

Pricing

InstrumentInternal RateExternal RateNotes
Talos Arctica$49/hr$80/hrFY26 (eff. July 2025). Internal ~$48.74/hr. External academic ~$79.77/hr.