Cryo-EMAccess policy not published

UCSF EM Core (W.M. Keck Foundation Advanced Microscopy Laboratory)

UCSF

📍 San Francisco, CA · Website ↗

The UCSF EM Core, formally the W.M. Keck Foundation Advanced Microscopy Laboratory, is located at the UCSF Mission Bay campus and provides high-end cryo-EM for biological samples. It operates two 300 kV Titan Krios (Krios 1, a G2 with XFEG, K3 and BioQuantum; Krios 2, a G4 with CFEG, Falcon 4i and Selectris X), a Talos Arctica and a Glacios (both K3), a Tecnai T12, an Aquilos 2 cryo-FIB with iFLM, and a Vitrobot Mark IV. The core also runs computing resources and developed UCSF MotionCor2.

Equipment Inventory(9 instruments)

Roster verified against the facility's own published instrument list, September 2026.

Aquilos 2

Thermo Fisher Scientific · Cryo-FIB Milling

FIB-SEM
Configuration: Cryo-FIB-SEM with iFLM and Nanosoft extended-run system for multi-day milling.

Vitrobot Mark IV

Thermo Fisher Scientific · Vitrification

Sample Prep

Glow Discharge System

Various · Glow Discharge

Sample Prep
Configuration: Grid glow discharge.

Cressington 208

Cressington · Coater

Sample Prep
Configuration: Carbon evaporator.

Titan Krios G2

Thermo Fisher Scientific · Single Particle / Tomography

TEM
Voltage: 300 kV
Configuration: Krios 1 / Titan Krios #1: 300 kV XFEG, Gatan K3 Summit, Gatan BioQuantum energy filter.

Tecnai T12

Thermo Fisher Scientific

TEM
Configuration: 120 kV LaB6, Gatan Rio 4k CCD; negative stain and sections.

Titan Krios G4

Thermo Fisher Scientific · Single Particle / Tomography

TEM
Voltage: 300 kV
Configuration: Krios 2 / Titan Krios #2: 300 kV CFEG, Falcon 4i, Selectris X.

Talos Arctica

Thermo Fisher Scientific · Single Particle / Screening

TEM
Voltage: 200 kV
Configuration: 200 kV XFEG, Gatan K3 Summit; screening and SPA data collection.

Glacios

Thermo Fisher Scientific · Single Particle / Screening

TEM
Voltage: 200 kV
Configuration: 200 kV XFEG, Gatan K3 Summit; narrow pole piece (Cs 1.65 mm); screening and small datasets.

Rates

This facility publishes its rates as a document rather than a web page. View the facility's rate document →