Cryo-EMAccess policy not published

Scripps Research Microscopy Core and cryo-EM instruments

Scripps Research

📍 La Jolla, CA · Website ↗

Scripps Research in La Jolla has no publicly listed cryo-EM core; the Cores and Services directory lists a Microscopy Core whose electron microscopes are a 120 kV FEI Talos L120C with Ceta 16M camera and a Hitachi S4800 SEM, with Leica ultramicrotomes and a GloQube glow discharger. The institute's high-end cryo-EM instruments (a Titan Krios with Gatan K2 Summit and a Talos, installed in 2014) are operated for the Department of Integrative Structural and Computational Biology and are documented only in a 2014 institutional news article. Their current configuration and access policy could not be verified from any primary web source.

Equipment Inventory(7 instruments)

Roster verified against the facility's own published instrument list, September 2026.

Leica EM UC7

Leica Microsystems · Ultramicrotome

Sample Prep
Configuration: Ultramicrotome; Microscopy Core

Leica EM UC6/FC6

Leica

Sample Prep
Configuration: Ultramicrotome with EM FC6 cryochamber; Microscopy Core

GloQube

Quorum · Glow Discharge

Sample Prep
Configuration: Glow discharge unit; Microscopy Core

Hitachi S4800

Hitachi

SEM
Configuration: FE-SEM with SE detectors, ExB filter, deceleration mode; Microscopy Core

Talos L120C

Thermo Fisher Scientific · Screening / Negative Stain

TEM
Voltage: 120 kV
Configuration: 120 kV, C-TWIN lens, cryo box, tomography holder and software, Ceta 16M CMOS camera; Microscopy Core

Talos Arctica

Thermo Fisher Scientific · Single Particle / Screening

TEM
Voltage: 200 kV
Configuration: 200 kV cryo-TEM installed 2014. Current detector configuration is not published.

Titan Krios

Thermo Fisher Scientific

TEM
Configuration: Installed 2014 with Gatan K2 Summit; ISCB cryo-EM facility, not the Microscopy Core; current detector/filter status unverified (evidence is a 2014 Scripps news article)