Cryo-EM✗ Internal Only

Electron Microscopy and Atomic Force Microscopy Core

City of Hope

📍 DUARTE, CA · Website ↗

City of Hope's Electron Microscopy and Atomic Force Microscopy Core in Duarte, California supports cryo-EM sample vitrification and imaging alongside conventional TEM and SEM services. The core runs FEI Tecnai TEMs fitted with cryo-transfer holders and cryo-stages that allow frozen specimens to be imaged below minus 170 degrees Celsius. A fully automated Vitrobot plunge-freezer is used to prepare vitrified grids for single-particle cryo-EM and cryo-tomography.

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Equipment Inventory(2 instruments)

Roster verified against the facility's own published instrument list, September 2026.

Vitrobot

Thermo Fisher Scientific

Sample Prep

Configuration: Fully automated vitrification device for plunge-freezing aqueous suspensions ahead of cryo-EM imaging.

Tecnai T12

×2

Thermo Fisher Scientific

TEM

Configuration: 120 kV TEM equipped with a Gatan Ultrascan 1000 2K CCD camera and a 70 degree tilt cryo-transfer holder for imaging frozen specimens below -170C.; TEM equipped with a Gatan 894 Ultrascan 1000 CCD camera, Gatan cryo-stage/box, and Gatan tomography holder.