Principal Scientist, Structural Biology

<div> <h2>Principal Scientist</h2> <p>We are seeking a Principal Scientist with deep expertise in Structural Biology to join our team in San Diego, CA. This is a highly collaborative and hands-on role spanning end-to-end workflows from protein construct design and protein production through high-resolution structure determination, contributing directly to drug discovery programs across multiple therapeutic areas.</p> <p>Internal Job Title: Principal Scientist I/II Location: onsite, San Diego, CA</p> <h3>About the Role:</h3> <p>At Novartis, we are reimagining medicine through scientific excellence and innovation. Within the Discovery Sciences organization, the Protein Sciences group plays a pivotal role in advancing early-stage drug discovery by enabling deep structural and functional insights into therapeutic targets. Structural Biology is a cornerstone capability, enabling structure-guided drug discovery for some of the most challenging and high-impact targets in medicine.</p> <p>This is a unique opportunity to join a world-class structural biology team within one of the largest and most innovative pharmaceutical companies. You'll have access to state-of-the-art instrumentation, highly skilled and collaborative colleagues, and the chance to make meaningful contributions to the discovery and development of life-changing medicines.</p> <h3>Key Responsibilities:</h3> <ul> <li>Lead and execute protein production and X-ray crystallography to elucidate protein-small molecule, prot